When laryngeal cancer is treated at an early stage, most of the larynx is preserved and a near-perfect sound can be achieved. In addition, it may not always be possible to protect the larynx in very advanced stages and it may be necessary to remove the entire larynx. In this case, since the continuity of the upper respiratory tract is disrupted in the patient whose entire larynx is removed, the patient has to breathe through a permanent hole in the throat.
Source: http://www.kbb.org.tr